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RX+DX= PPH Risk: What prescription dispensing data tells us about antidepressants and risk of postpartum hemorrhage.

October 1st, 2013 by avatar

 Regular contributor (and brand new PhD!) Walker Karraa shares a new study examining the relationship between antidepressant medication and postpartum hemorrhage.  Walker questions the lead researchers on other factors present during labor and birth that may have as much or more impact on the likelihood of PPH, as the influence of antidepressant medication and inquires if those factors were examined.  Read Walker’s assessment and interview and share in the comments section your thoughts on this research.  How might you respond to students, patients and clients who ask about this potential increased risk of hemorrhage?  - Sharon Muza, Community Manager, Science & Sensibility

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© www.revolutionpharmd.com

A recent study, Use of antidepressants near delivery and risk of postpartum hemorrhage: Cohort study of low income women in the United States (Palmsten, Hernándéz-Diaz, Huybrechts, Williams, Michels, Achtyes, Mogun, & Setogouchi, 2013) is described as:

“This study is the first to report an association between exposure to antidepressants at the time of delivery and risk of postpartum hemorrhage in a US population and in a population with a diagnosis of depression” (p. 6). Further inquiry into the study provides ample opportunity to consider the intersection of method, measurement and maternal mental health with regards to the use of antidepressant medication and potential risks.

RX: Prescription-dispensary records

The objective of this epidemiological cohort study was to “determine whether use of serotonin or non-serotonin reuptake inhibitors near to delivery is associated with postpartum hemorrhage” (Palmsten et al., 2013, p. 1). The methods involved analyzing pharmacy dispensing records of 106,000 women, ages 12-55, previously identified through Medicaid Analytic eXtract (MAX) who had live births between the years 2000 and 2007, and had been given a medically coded diagnosis of mood or anxiety disorder as defined by the ICD-9 codes (296.x, 300.x, 309.x, or 311.x). Outcome was identified as women who had received an ICD-9 code for postpartum hemorrhage (666.x), atonic postpartum hemorrhage (666.1x), and only inpatient postpartum hemorrhage (Palmsten, et al., 2013).

DX: Connecting diagnosis to depression

Citing a 2000 Canadian epidemiological study (West, Richter, Melfi, McNutt, Nennstiel & Mauskopf), the authors determined that being given the medical code with one of the aforementioned diagnoses was a reasonable predictive measurement of maternal depression. Palmsten et al., (2013) stated “The positive predictive value for depression with these codes was 77%, indicating that most women in this subcohort likely had depression” (Palmsten, et al., 2013, p. 2).

Measuring exposure to antidepressants was addressed by dividing the women of this large cohort into four groups based on their pharmacy dispensing data: (a) current, or antidepressant dispensing supply that overlapped with the delivery date, (b) recent, or antidepressant dispensing supply on at least 1 day in the 1-30 days before delivery date, (c) past, or antidepressant dispensing supply ending between 1-5 months before delivery date, and (d) a reference group with “no exposure”, or no record of antidepressant dispensing supply in the five months before delivery.

I am very grateful to the study’s lead author, Dr. Kristin Palmsten, and senior author, Dr. Soko Setoguchi for taking the time to unpack the pharmacoepidemiological methodology used in this study, and offer suggestions for how childbirth professionals can address findings in practice.

WK: Can you explain the use of prescription dispensing data with regards to estimating exposure at the time of delivery in lay terms?

KP and SS: In our study, we had information on the date a woman was dispensed an antidepressant prescription, the type of antidepressant received, and the number of days for which the prescription was intended to cover. Using this information, we estimated whether a woman had antidepressants available near the time of delivery. Because women may not have taken antidepressants on the days we assumed, there will be some error in our measurement of the exposure. However, this is the best available measurement for drug exposure in studies with large numbers of women like ours.

WK: How does a prescription dispensing data collection measure blood serum platelet levels of exposure? Given that prescription dispensing data is an epidemiological estimate, what would you suggest is the best language to use when describing estimated, relative, or actual risk of postpartum hemorrhage if a woman is taking an SSRI or a non-SSRI prior to delivery?

KP and SS: The risk for postpartum hemorrhage was 2.8% for women not using antidepressants and it was 3.9% for women who were exposed to antidepressants near the time of delivery. We did not have biologic samples available to assess antidepressant exposure.

Given the breadth of the study and potential implications of assumed causality, I then asked the authors for feedback on their following concluding statements (Palmsten, et al., 2013):

• “Although we cannot rule out residual confounding, our study indicates that there might be
about one excess case of postpartum hemorrhage for every 80 to 100 women using antidepressants near the time of delivery, if we assume causality” (p. 6);
• “Our study suggests that all classes of antidepressants are associated with an increased risk for abnormal bleeding” (p. 6);
• “The absolute increase in risk associated with antidepressant exposure in the month before delivery is small, but women and their physicians should be aware of the potential risks when making treatment decisions near the end of pregnancy” (p. 6).

WK: Based on these statements, how would you recommend childbirth educators respond to women’s concerns regarding the use of SSRI and non SSRI in pregnancy?

KP and SS: Our study found that women who use SSRI or non-SSRI antidepressants near the time of delivery had an increased risk for postpartum hemorrhage. We could not exclude the possibility that other factors associated with antidepressant use might actually have caused postpartum hemorrhage, and it is important to remember that the increase in risk of postpartum hemorrhage among antidepressant users is small. In our study, the risk for postpartum hemorrhage was 2.8% for women not using antidepressants and it was 3.9% for women using antidepressants near the time of delivery. These findings as well as the harmful effects of untreated depression should be considered in decisions regarding antidepressant use during pregnancy.

WK: How do you see the risk of exposure to “all classes of antidepressants” in consideration of the literature demonstrating the adverse effects of untreated perinatal mood and anxiety disorders on fetal development, birth, and postpartum health and wellness of mother and baby?

KP and SS: Practitioners and pregnant women should consider and balance the potential risks of antidepressants and the harmful effects of untreated depression and depressive relapse on maternal and offspring health.

WK: How would you address the impact of the underlying disorder in the assessment of risk? For example, depressed women are more likely to be overweight/obese, which is also associated with hemorrhage. (Blomberg, 2011).

KP and SS: We cannot rule out the possibility that obesity, alcohol use, drug use, or other factors related to maternal depression or the severity of the depression; contribute to the higher risk of postpartum hemorrhage among women who use antidepressants during pregnancy. This uncertainty of our results should be a part of the antidepressant treatment decision by practitioners and pregnant women.

WK: Regarding potential mediators, your study included delivery characteristics of short labor, long labor, forceps or vacuum extraction and induced labors. For induction, was protocol considered? For example, use of Cervadil or not, or the length of time and levels of Pitocin given prior to delivery? How might you look forward to including data like this in future analyses?

KP and SS: We did not have information on the type or duration of induction. Further studies are needed to confirm our results and these would be important factors to consider in future studies.

WK: How do you perceive the relationship between these findings and pain management in labor and delivery?

KP and SS: We did not assess the role of pain management in this study, but pain management and epidural use are important factors to consider in future studies.

WK: Childbirth educators are often interested in the relationship between outcome measures and hospital labor and delivery protocol. Many hospitals have protocols regarding external fetal monitoring (EFM) that requires being in bed, and not eating or drinking in labor. For a woman who is also on an SSRI or non SSRI, how might either or both of these practice protocols confound exposure and risk of postpartum hemorrhage stated in this study? (Particularly because serotonin receptors in the gut involved in metabolizing SSRIs?)

KP and SS: Many factors influence bioavailability of antidepressants and birth outcomes. We did not have information on EFM in our study and we cannot speculate how EFM interact with antidepressants and postpartum hemorrhage.

WK: How might APGAR scores of infants be considered within this discussion?

KP and SS: While we did not have APGAR scores in our database, the impact of maternal mood and anxiety disorders and maternal antidepressant use on infant outcomes is another critical piece to be considered in the balance of antidepressant treatment decisions around the time of pregnancy.

WK: Unfortunately, many medical care providers do not screen for perinatal mood and anxiety disorders in pregnancy, despite validated and available short tools available (such as PH-Q-9 or PHQ-2). In assessing exposure to antidepressant medication and increased risk for postpartum hemorrhage, how do you see your data potentially bridging that gap?

KP and SS: We hope this study and others on antidepressant safety during pregnancy underscore the importance of maternal mood and anxiety disorders on pregnancy outcomes, the complex treatment decisions that women with mood and anxiety disorders face, and the importance of discussing treatment options before, during, and after pregnancy with patients.

Conclusion

The opportunity to create cross disciplinary dialogue connecting reader with research, researcher with reader creates the causes for future collaboration, increased understanding, and growth in the field. Given the findings posited in this study, the scope and limitations of the prescription dispensing epidemiological methods—there is much to learn regarding the issue of antidepressants and postpartum hemorrhage. Pharmacy dispensing records cannot measure the exposure perfectly, as having a prescription does not insure consuming the prescription. As noted by the authors, bioavailability of blood serum was not a resource. Controlling for timing, dosage, frequency, missed doses, or titration cannot be measured through prescription records, yet the authors concluded the records and analyses of the records estimate a likelihood of exposure and conclude risk of increased chance of postpartum hemorrhage.

As increased awareness of maternal mortality brings our understanding of the significance of further research into preventing PPH, critical analysis of the relationship, or lack of relationship, between perinatal mood and anxiety disorders and psychopharmacological treatment must continue to develop. I look forward to seeing the next phase of research that emerges from the work of this team, and thank them for their contribution to the discussion.

Correspondence regarding this research paper may be directed to the lead author, Dr. Kristin Palmsten.

References

Blomberg, M. (2011). Maternal obesity and risk of postpartum hemorrhage. Obstet Gynecol,118 (3):561-8. doi: 10.1097/AOG.0b013e31822a6c59.

Palmsten, K., Hernándéz-Diaz, S., Huybrechts, K. F., Williams, P. L., Michels, K. B., Achtyes, E. D., Mogun, H. & Setogouchi, S. (2013). Use of antidepressants near delivery and risk of postpartum hemorrhage: Cohort study of low income women in the United States. BMJ, 347:f4877 doi:10.1136/bmj.f4877.

Salkeld, E., Ferris, L. E., & Juulink, D. N. (2008). The risk of postpartum hemorrhage with selective serotonin reuptake inhibitors and other antidepressants. Journal of Clinical Psychopharmacology, 28, 230-234.

West, S.L., Richter, A., Melfi, C.A., McNutt, M., Nennstiel, M.E., & Mauskopf, J. A. (2000). Assessing the Saskathchewan database for outcomes research studies of depression and its treatment. Journal of Clinical Epidemiology, 53, 823-831.

Childbirth Education, Guest Posts, Maternal Mental Health, New Research, Postpartum Depression , , , , , , ,

Perception of Social Support and Increased Risk of PPD in Cities: Research Review

August 27th, 2013 by avatar

Today, regular Science & Sensibility contributor Walker Karraa shares a study that came out earlier this summer examining the incidence of postpartum depression and place of residence (rural vs urban.)  Women living in urban areas were more likely to suffer from PPD.  Are you surprised?  Why do you think that might be?  Take a look at the information Walker shares and join the conversation in the comments section.  If you work in an urban setting, are you doing everything you can to help mothers with this increased risk? Let us know. – Sharon Muza, Community Manager

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A new Canadian study has examined the relationship between place of residence and risk of developing postpartum depression (PPD) based on population-based sample. Vigod, Tarasoff, Bryja, Dennis, Yudin, & Ross (2013) presented Relation between place of residence and postpartum depression in the early release at Canadian Medical Association. The study is a comprehensive and complex analysis of the statistical indicators related between where women live and the risk for developing postpartum depression (PPD.) For childbirth professionals who practice in urban settings, the findings here underscore the need for heightened awareness of the issues of support and awareness regarding maternal mental health in pregnancy and postpartum.

source: futurity.org

An overview of the study objectives, design, methods, and results has been compiled. Finally, a brief discussion as to the role of childbirth professionals is offered, and resources are provided.

Objectives

The objectives of this study were as follows:

  1. To compare the risk of PPD among Canadian women living in rural and urban areas
  2. To identify factors that could explain any associations between place of residence and risk of postpartum depression (Vigod, et al., 2013, p. 1)

Design

Sample: Women who had recently given birth and responded to the 2006 Canadian Maternity Experiences Survey through the Public Health Agency of Canada and the Canadian Perinatal Surveillance System were contacted. The study is a comprehensive and complex analysis of the statistical indicators related between where women live and the risk for developing PPD.

Stratified sampling by province or territory ensured sample size and a simple random sample without replacement was pulled from each stratum.  Inclusion consisted of women age over 15 who had singleton birth and were living with their child at the time of the interview. Response rate of 78% were collected via telephone and computer assisted interview resulting in 6421 of 8244 women contacted, representing 76, 500 Canadian women nationally. The final sample was 6126.

Outcome Measure: All women were administered the Edinburgh Postnatal Depression Scale (EPDS; Cox, Holden, Sagovsky, 1987). Risk of PPD was operationalized as anyone with a score of < 13 points.

Definitions of populations. The authors defined the types of populations as follows:

  • Rural: populations outside the settlements of 1000 or more people or outside areas with a population density of 400 more inhabitants per square kilometer (p. 2)
  • Semi-rural: population <30,000
  • Semi-urban: population 30,000-499,999
  • Urban: > 500,000

Additionally, the authors implemented a metropolitan-influence component in defining and compartmentalizing different populations:

To separate the women with the most potential for social isolation from those with less potential for isolation, we further divided women living in rural and small town areas by ‘metropolitan-influenced zone’. These zones indicate the percentage of residents who commute to urban centers. The zones are designated as strong (> 30% residents commute to urban core), moderate (5%-29% commute), weak (> 0%, but <5%) or no (0%) metropolitan influence. (Vigod, et al., 2013, p. 2)

Methods

A thorough panel of covariates was administered to data analysis, including: age, parity, marital status, SES, educational status, and country of birth, recent immigration (within 5 years), and distance travelled to birth. In addition, history of depression, substance/alcohol use and life stressors such as interpersonal violence, abuse, and social support during pregnancy and postpartum period were factored.  Medical covariates of complications during perinatal period included preterm birth, birth weight, NICU, and cesarean section. All data were analyzed through SAS version 9.3.

Findings

We found that Canadian women who lived in large urban areas (i.e., population > 500,000 inhabitants) were at higher risk of postpartum depression than women living in other areas. The risk factors for postpartum depression (including history of depression, social support and immigration status) that were unequally distributed across geographic regions accounted for most of the variance in the rates of postpartum depression. (Vigod et al., 2013, p. 5)

The authors noted that immigration status, interpersonal violence, and self-perceived health and social support were responsible for the variance. For example, in the area of perceived social support in pregnancy and postpartum, the following findings were noted in the table below. 

 Conclusions

The authors noted that modifiable risk factors included social support in pregnancy and postpartum. Childbirth professionals working in cities can provide invaluable social connectivity and access to key resources targeting this issue.  Issues of dislocation, immigration status, and domestic violence are risk factors for higher incidence of PPD that need to be addressed in education, training and curriculum. Resources for domestic violence and legal advocacy have been provided.  Each professional can create ways to offer the material to students and clients that remains within a scope of practice as defined by their certifying organization, and that resonates with h/her personal style and community needs. Please feel free to add to the list of resources!

 Resources

Postpartum Support International (resources in Spanish as well)

Interpersonal violence resources

National Domestic Violence Hotline: Staffed 24 hours a day by trained counselors who can provide crisis assistance and information about shelters, legal advocacy, health care centers, and counseling.

1-800-799-SAFE (7233); 1-800-787-3224 (TDD)

Domestic Violence Fact Sheets

Domestic Violence State Hotlines

Learn more for your own continuing education at the Department of Justice Office of Violence Against Women.

References

Cox, J. L., Holden, J. M., & Sagovsky, R. (1987). Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. The British journal of psychiatry, 150(6), 782-786.

Vigod, S. N., Tarasoff, L. A., Bryja, B., Dennis, C. L., Yudin, M. H., & Ross, L.E. (2013).  Relation between place of residence and postpartum depression. Journal of Canadian Medical Association. doi:10.1503/cmaj.122028.

 

Childbirth Education, Guest Posts, Infant Attachment, Maternal Mental Health, Postpartum Depression, Research, Uncategorized , , , , , ,

Perinatal Mental Health and Childbirth Education: Professional Perspectives Part II

December 11th, 2012 by avatar

By, Walker Karraa

Regular contributor Walker Karraa has written an excellent three part series on Perinatal Mood and Anxiety Disorders (PMAD) and what the childbirth educator or birth professional can do to help women get the help they may need when dealing with mental illness during the prenatal and postpartum period.  Walker interviews experts in the field who all offer concrete steps, activities and resources so that educators and others can do to be more prepared to discuss this important subject with students and clients.  Recent press coverage of a British mother suffering from severe PMAD has made headlines and the topic is one that belongs in whatever childbirth class a woman chooses to take.  The first post in the series is here  Part III will appear on Dec 13th, 2012.– Sharon Muza, Community Manager.

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http://flic.kr/p/adyga

We have the opportunity to hear another expert perspective regarding the use of antidepressants, stigma, and the role childbirth education might play in the prevention of perinatal mood and anxiety disorders (PMAD). This installment features Nancy Byatt, D.O., MBA. Dr. Byatt is a perinatal psychiatrist and Assistant Professor of Psychiatry and Obstetrics & Gynecology at University of Massachusetts Medical School/UMass Memorial Medical Center.  Dr. Byatt’s research focuses on understanding and evaluating ways to improve depression outcomes for perinatal women and their children through health care system improvement.  Her current research aims to improve the uptake of evidence-based treatments for perinatal depression in obstetric settings.  I know I speak for Lamaze International in thanking Dr. Byatt for participating.

WK: What can we do to increase the understanding that a woman’s mental health is part of maternal health?  

Dr. Byatt: Providing psychoeducation to women and their partners about the importance of perinatal mental health is a good first step.   Psychoeducation should aim to destigmatize depression and other perinatal mental health concerns and encourage women to engage in treatment.  Providing psychiatric resource and referral source guides may also empower women to seek treatment.  Childbirth educators could also be trained in motivational enhancement interventions that may inspire women to address their mental health concerns.  For example, providing information about health risks, wellness interventions, support groups, psychotherapy, medication options, and other mental health resources can encourage women to engage in treatment.

WK: How might childbirth professionals integrate perinatal mood disorders in classes? 

Dr. Byatt: Childbirth education classes are an excellent opportunity to prepare women and their partner or primary support for the emotional transition to the postpartum period.  Ideally, women should be taught how to take care of themselves both physically and emotionally during this vulnerable time period.  Women and their partners or primary support could be given information about the signs and symptoms of depression so they can recognize depression if it occurs.  It would also be helpful to destigmatize depression and review mental health resources.  Psychoeducation could also be provided about what factors may put women at higher risk for a perinatal mood disorder.

WK: How would you describe the stigma of perinatal mental health disorders and its impact?

Dr. Byatt: Many studies have demonstrated that many women feel very ashamed of perinatal depression and as a result may be less likely to seek help.  More specifically, women may be afraid that they will lose parental or personal rights if they disclose psychiatric symptoms.  They may also fear feeling judged by perinatal health care professionals and/or friends and family.   Acknowledging depression symptoms can also negatively impact women’s view of themselves as a mother.   Unfortunately, these concerns may result is avoidance of mental health discussions.

WK: What do you see as the most significant barriers to treatment for women with PMADs?

Dr. Byatt: Women face many barriers to accessing and seeking help for perinatal depression. Stigma and shame have been consistently reported in numerous studies.  Studies also suggest that interactions with perinatal health care professionals may discourage help-seeking. Some women also report that their emotional needs are not addressed by perinatal health care professionals, perceiving them as unresponsive or unsupportive.  Women also perceive that perinatal health care professionals lack training in regards to perinatal mental health.  Available treatment resources are often limited for both perinatal women and obstetric providers and staff, creating both patient and provider barriers, respectively.

Some typical (but not all inclusive) symptoms of Postpartum Mood and Anxiety Disorders

  • Are you feeling sad or depressed?
  • Do you feel more irritable or angry with those around you?
  • Are you having difficulty bonding with your baby?
  • Do you feel anxious or panicky?
  • Are you having problems with eating or sleeping?
  • Are you having upsetting thoughts that you can’t get out
  • of your mind?
  • Do you feel as if you are “out of control” or “going crazy”?
  • Do you feel like you never should have become a mother?
  • Are you worried that you might hurt your baby or yourself?

Women note numerous factors that impede their ability access mental health treatment, including disconnected pathways to depression care.  Women’s interactions with mental health providers can also be perceived as a barrier to treatment. Women may find it hard to access mental health care due to long wait times or lack of available providers. Women may not know who to call or how to get help or have difficulty finding a mental health provider willing to see perinatal women.  

WK: How would you respond to media-based concerns regarding the safety of SSRI medication in pregnancy? 

Dr.  Byatt: It is imperative to consider risk of untreated depression when considering medication or non-medication treatment during pregnancy.  Multiple studies have demonstrated that perinatal depression can negatively impact mother, infant, child and family.   Maternal depression has been associated with emotional and functional disability in children of depressed mothers.  Although risks have been reported with SSRI use in pregnancy, the preponderance of data is reassuring.

The risks and benefits of treatment with antidepressants should be weighed against the risks of untreated illness.  Does exposure to the antidepressant or untreated illness pose a greater risk?    If treatment with an antidepressant is indicated, then a discussion of the risks and benefits should take place before medication is prescribed.  Pharmacotherapy should be used judiciously and treatment should aim to maximize evidence-based non-medication treatments, such as psychotherapy, in order to maintain or reach remission of the maternal symptoms.

WK: What are your thoughts regarding discontinuation of medication in pregnancy?

Dr. Byatt: Clinical decisions should be based on the risks, benefits and alternatives to medication treatment.  Untreated maternal illness and the potential risks of psychotropic medication must be considered.  It is vital to consider women’s treatment preferences, illness severity, and the risks of no treatment and under-treatment.  Discontinuation of an effective medication often poses more risk than continuation because it carries the risk of relapse and/or in utero exposure to a second antidepressant.

WK: What suggestions do you have regarding how childbirth organizations can encompass perinatal mental health into training curriculum and practice?

Dr. Byatt: A combination of staff training, structured screening programs, and community resource guides may help childbirth education organizations encompass perinatal mental health training into their curriculum and practice.  Training childbirth educators in mental health can allow them to feel more confident discussing perinatal mental health, which in turn may mitigate women’s fears and concerns and activate them to seek treatment.

Conclusion:

I wonder about the perception of lack of training in childbirth education courses as a part of the barrier to treatment noted by Dr. Byatt. Disconnected pathways to care seem a call to action for childbirth professionals. Where women and families find lack of education, empathy, and acceptance –childbirth professionals could provide pathways to better treatment merely through community resource lists.  Training, structured screening programs and community resource guides are good suggestions to not only optimize care for women, but to optimize practices for educators.

If you took inventory of the training and resources you have been given regarding perinatal mental health—what would you find? Do you know what resources are available from your certifying organization for you to use in your classes? Have you read Kathy McGrath’s article on the Lamaze.org website on Baby Blues? What are some of your favorite resources and activities that you use in class to cover these topics? How do you envision your childbirth organization creating or growing pathways in the future to support continued education on this topic?

Check

About Nancy Byatt, DO, MBA

Nancy Byatt, DO, MBA:  Dr. Byatt’s clinical, educational and research efforts have been led her numerous publications and awards including the Briscoli Award for Resident-Faculty Academic Collaboration and APA/APIRE Junior Investigators Award.   She recently submitted a Career Development Award Proposal to the NIH/NIMH (National Institute of Health/National Institute of Mental Health) in order to develop and evaluate a new low-cost program that aims to improve the delivery of depression care in outpatient obstetric settings.  Her recent publications include:

1. Byatt N, Biebel K, Lundquist R, Moore Simas T, Debourdes-Jackson G, Ziedonis D.  Patient, Provider and System-level Barriers and Facilitators to Addressing Perinatal Depression:  Perspective of Obstetric Providers and Support Staff. Journal of Reproductive and Infant Psychology.  Link to article:  http://dx.doi.org/10.1080/02646838.2012.743000

2. Byatt N, Biebel K, Debourdes-Jackson G, Lundquist R, Moore Simas T, Weinreb L, Ziedonis D.  Community Mental Health Provider Reluctance to Provide Pharmacotherapy May Be a Barrier to Addressing Perinatal Depression: A Preliminary Study. Psychiatric Quarterly, 2012; ePub ahead of print DOI: 10.1007/s11126-012-9236-0.

3.  Byatt N, Moore Simas T, Lundquist R, Johnson J, Ziedonis D. Strategies for Improving Perinatal Depression Treatment in North American Outpatient Obstetric Settings. Journal of Psychosomatic Obstetrics & Gynecology. 2012 Dec;33(4):143-61. doi: http://www.ncbi.nlm.nih.gov/pubmed/23194018

4. Byatt N, Deligiannidis K, Freeman M.  Antidepressant Use in Pregnancy:  A Critical Review Focusing on Controversies and Risks. Acta Psychiatrica Scandinavica. In Press.

 

Babies, Childbirth Education, Depression, Guest Posts, Infant Attachment, Maternal Mental Health, Newborns, Perinatal Mood Disorders, Postpartum Depression , , , , , , , , , , ,

Research in Review: Reducing PPD Symptoms Among Black and Latina Mothers

May 24th, 2012 by avatar

This is a post by Science & Sensibility’s regular contributor, Walker Karraa, MFA, MA, CD(DONA)

The recently published study, “Reducing Postpartum Depressive Symptoms Among Black and Latina Mothers: A Randomized Controlled Trial” (Howell et al., 2012) has garnered attention among birth and perinatal mental health professionals.  The intention of this post is to (a) present the evidence given in the study; and (b) encourage community discussion, exploration, and solution-driven strategies for childbirth education practices that address postpartum depressive symptoms in communities of color.

Study Breakdown: Objectives and Rationale

The objective of the randomized controlled study was to “estimate the effectiveness of a behavioral educational intervention to reduce postpartum depressive symptoms among minority mothers” (p. 942).

The rationale for the study itself included the current quantitative data demonstrating the public health problems presented by the high prevalence of postpartum depressive symptoms in American women, and the subsequent negative effects of depressive symptoms on maternal quality of life, mother-infant attachment, and the impact of those symptoms on the social, cognitive, and emotional development of children (cited studies: Gaynes et al., 2005; Howell, Mora, Horowitz, & Leventhal, 2005; Martin et al., 2006; Zayas, Cunningham, McKee, & Jankowski, 2002). Most relevantly, rationale for a study examining African American and Latina mothers specifically was based in evidence of three previous studies that have demonstrated “the burden of postpartum depressive symptoms is especially high in low-income black and Latina women” (p. 942; cited studies: Das, Olfson, McCurtis, & Weissman, 2006; Howell et al., 2005; Lewis-Fernandez, Das, Alfonso, Weisman, & Olfson, 2005).

In this study, Howell, et al., (2012) offered that the rationale for generating a behavioral educational intervention was also rooted in previous research findings that “situational factors such as postpartum physical symptoms, overload from daily demands, and poor social support play a major role in the generation of depressive symptoms” (p. 942, cited studies: Howell et al., 2005; Howell, Mora, DiBonaventura, & Levanthal, 2009; Howell, Mora, & Levanthal, 2006).

 Methods: How Did They Do the Study?

  • Recruitment: 540 self-identified black and Latina mothers recruited to participate during their postpartum hospital stay at a “large tertiary inner-city hospital located in East Harlem in New York City” (p. 943). Inclusion criteria included participants who self-identified as black or Latina, 18 years or older, with neonates weighing 2,500g or higher, with 5-minute Apgar score of >7.
  • Randomization: Randomization of groups occurred through approved procedure of computerized randomization of participant number. Research coordinators were blinded to the assignment of the study arm of those who would receive the intervention and the control arm that received enhanced usual protocol.

 Intervention: What did they do?

For the group assigned to the intervention, the following 2 steps were taken:

Step 1:

“The in-hospital component of the intervention involved a 15-minute review of an educational pamphlet and partner summary sheet by the mother with a Masters-trained bilingual social worker” (Howell, et al., 2012, p. 943)

 What was in the pamphlet?

“The pamphlet represented each potential trigger of depressive symptoms as a “normal” aspect of the postpartum experience and provided specific suggestions for management. For example, the prevalence of moderate or heavy vaginal bleeding immediately postpartum was depicted by eight of 10 female silhouettes colored red; only one of 10 was red 3 months postdelivery. Simple “to do” statements (rest; use pads) were listed between the two rows of figures.  A separate page was dedicated to social support and ‘helpful organizations’ were listed” (Howell, et al., 2012, p. 943).

 What was the “partner summary sheet”?

The partner summary sheet spelled out the typical pattern of experience for mothers postpartum, i.e., it was designed to “normalize” the feelings and behaviors experienced and enacted by most mothers postpartum and stressed the importance of social support for the patient. The social worker reviewed the patient education pamphlet and partner summary sheet with the patient during her postpartum hospital stay and answered questions (Howell, et al., 2012, p. 943).

 Step 2:

A phone call 2 weeks post-delivery by a social worker was placed to each mother in the intervention group to assess symptoms, symptom management skills, and to review the “to-do” lists in the pamphlets.

Istock/aabejon

 Results: What Did They Find?

The authors compared the group of mothers who did not receive the intervention to the intervention group and published the following results:

  • Positive depression screens were less common among the intervention group compared with the non-intervention group at 3 weeks (8.8% compared with 15.3%, P=.03), 3 months (8.4% compared with 13.24%, P=.09), and 6 months (8.9% compared with 13.7%, P=.11).
  • Analysis for up to 6 months follow-up demonstrated that:

“Mothers in the intervention group were less likely to screen positive for depression compared with enhanced usual care (odds ratio 0.67, 95% confidence interval 0.47-0.97)” (Howell, et al., 2012, p. 948).

Implications

Here the authors noted that implications were that behavioral education could address and modify risk factors that have been shown to correlate with postpartum depressive symptoms. Increasing mothers’ knowledge about triggers, and the “to-do” list of management of those triggers, followed by the phone contact with trained social worker provided an intervention that demonstrated significance in reduced postpartum symptomatology for this study.  Authors noted that implementing visual modalities in educational materials assisted mothers’ understanding of the triggers, and the range of “normal” symptoms that could be addressed with behavioral strategies, and re-examined in a timeframe of normalcy.

 Limitations

The authors noted that limitations included potential lack of generalizability, as the study took place in one site; they suggested future research in multiple settings would be indicated.

Food for Thought

How does the study inspire ways in which you might most effectively address postpartum symptoms, their triggers, and education with your clients? What are some ways you might use this information in your childbirth education classes?

And lastly, perhaps deeper still, can we truly engage this topic without discussing the role of racism plays in creating barriers to treatment, stigma, and lack of access to care for women of color? What are the steps childbirth and doula organizations can take toward addressing this issue? I would suggest position papers on perinatal mental health and racial disparities would be first line action items for organizations to implement publicly. Outreach to public health and mental health professionals from the organizational level, would further support birth professionals to gain the knowledge and tools needed to acknowledge and address these issues, and become active participants in substantive social change for the future of childbearing women. How many of our organizations are listed in educational pamphlets on postpartum depression as “helpful organizations”?

Walker Karraa, MFA, MA, CD(DONA)

Walker is currently the President of PATTCh, a not for profit founded by Penny Simkin and Phyllis Klaus–dedicated to the Prevention and Treatment of Traumatic Childbirth. Walker is a doctoral candidate at Institute of Transpersonal Psychology, a certified birth doula, writer, and maternal mental health advocate.  She holds an MA degree in Clinical Psychology from Antioch University Seattle, and a BA and MFA degree in dance from UCLA.  Walker is a contributor to the Lamaze sites, www.givingbirthwithconfidence.org and www.scienceandsensibility.org.  She lives in Sherman Oaks, California with her husband, and two children.

References

Das, A., Olfson, M., McCurtis, H., & Weissman, M. (2006). Depression in African Americans: Breaking barriers to detection and treatment. Journal of Family Practice, 55, 30-39.

Gaynes, B., Gavin, N., Meltzer-Brody, S., Swinson, T., Gartlehner, G., Brody, S., & Miller, W. (Ed.). (2005). Perinatal depression: Prevalence, screening accuracy, and screening outcomes (Summary, evidence report/technology assessment No. 119). Rockville, MD: Agency for Healthcare Research and Quality.

Howell, E. A., Balbierz, A., Wang, J., Parides, M., Zlotnick, C., & Leventhal, H. (2012). Reducing postpartum depressive symptoms among Black and Latina mothers: a randomized controlled trial. Obstetrics & Gynecology, 119(5), 942-949. doi:10.1097/AOG.0b013e318250ba48

Howell, E. A., Mora, P. A., Horowitz, C. R., & Leventhal, H. (2005). Racial and ethnic differences in factors associated with early postpartum depressive symptoms. Obstetrics & Gynecology, 105, 1442-1450.

Howell, E., Mora, P., Chassin, M., & Levanthal, H. (2010). Lack of preparation, physical health after childbirth, and early postpartum depressive symptoms. Journal of Women’s Health (Larchmont), 19, 703-708.

Howell, E., Mora, P., DiBonaventura, M., & Levanthal, H. (2009). Modifiable factors associated with changes in postpartum depressive symptoms. Archives of Women’s Mental Health, 12, 113-120.

Howell, E., Mora, P., & Levanthal, H. (2006). Correlates of early postpartum depressive symptoms. J Maternal Child Health, 10, 149-157.

Lewis-Fernandez, R., Das, A., Alfonso, C., Weisman, M., & Olfson, M. (2005). Depression in US Hispanics: Diagnostic and management considerations in family practice. Journal of American Board of Family Practice, 18, 282-296.

Martin, J. A., Hamilton, B. E., Sutton, P. D., Ventura, S. J., Menacker, F., & Kirmeyer, S. (2006). Births: final data for 2004. National Vital Statistical Report, 55, 1-101.

Zayas, L., Cunningham, M., McKee, M., & Jankowski, K. (2002). Depression and negative life events among pregnant African-American and Hispanic women. Women’s Health Issues, 12, 16-22.

 

Childbirth Education, Depression, Guest Posts, Maternal Mental Health, Perinatal Mood Disorders, Postpartum Depression, Walker Karraa , , , , , , ,

Analyzing Information on the Web: The Best Postnatal Mental Health Websites

January 10th, 2012 by avatar

Later this month, Science & Sensibility contributors will share their hopes for the year 2012: what we would like to see accomplished in the ensuing months on behalf of mothers, babies and families, and the maternity care industry as a whole.  One of my hopes for the coming year(s) is that childbirth education organizations like Lamaze will increase their attention to issues revolving around maternal mental health; training birth professionals to screen, recognize, support and appropriately refer women with whom they work who may be suffering from one of the myriad perinatal mood disorders (PMDs)we now understand exists.

To that end, I’d like to share with you a study that recently crossed my desk (thank you, Walker Karraa) which assessed online resources pertaining to PMDs.  Donna Moore and Susan Ayers published their findings from A Review of Postnatal Mental Health Websites: Help for Healthcare Professionals and Patients in the Archives of Women’s Mental Health in November of last year.  The aim of the study was to conduct a systematic review on any and all current websites that maintain a primary purpose of discussing postnatal health with particular interest in the depth, breadth, quality and technological excellence of sites that specifically discuss postnatal mental health. 

 

Studies show that 10–15% of new mothers are diagnosed with postnatal mental illnesses, and potentially one in four women may have significant distress without meeting criteria for a disorder.” (Baker et al. 2009a, b;Czarnoka and Slade 2000)… However, there is now increasing evidence that anxiety disorders are also prevalent in between 3% and 43% of women in the postpartum period (Glasheen et al. 2009).”

The four major search engines were employed (Google, Bing, Ask Jeeves and Yahoo) and the top 25 results for each key word entered were then analyzed.

Disappointingly, the publication of results does not list all sites scrutinized (I would like to see what their search results generated) but the authors did list the top five websites, according to their criteria for excellence which included accuracy of information, available resources for mothers, and website (technical) quality:

Table 1
*Table 1 re-purposed directly from publication

 

The websites were examined for their quality of information and navigability based on the basic criteria list above, as well as by the following sub-categories:

1. Accuracy of Information
a. symptoms (of postnatal mood disorders…not only PPD but anxiety, psychosis and PTSD

b. risk factors (psychosocial, medical history and additional factors)
c. impact (of postnatal mood disorders upon the mother, infant and her partner/family)

2. Available Resources
a. self-help
b. tools for mothers
c.  support for mothers
d.  additional resources.

3. Website Quality
a. authority
b. contact ability
c. up-to-date
d. navigation
e. presentation
f. advertisements (appropriateness or lack there-of, distracting, misleading…)
g. accessibility

 

As concluded by the authors:

 

Information was often incomplete and tended to be about symptoms, predominantly depressive symptoms, such as tearfulness. Coverage of other symptoms of anxiety, puerperal psychosis or PTSD was minimal. This could reinforce the misconception that postnatal mental illness is solely depression or simply an extension of the ‘baby blues’.”

What type of information, as certifying organizations, are we providing our educators?  What kind of information are we, as childbirth educators, providing our clients?  Are we providing information that is accessible (understandable), readily available (are we not shying away from difficult-to-discuss topics) and high quality (evidence-based)?  Are we acknowledging that somewhere between ten and forty-three percent of the women we teach will end up suffering a postnatal mood disorder?  Are we discussing risk factors and approaches to late pregnancy and birth that might help them avoid this outcome?

 

Invitation for reader feedback:  How are YOU implementing postnatal (or perinatal) mood disorders into your curriculum?


Posted by:  Kimmelin Hull, PA, LCCE, FACCE

Childbirth Education, Perinatal Mood Disorders, PTSD , , , , , , , , , ,